Transfusion in Gastrointestinal Bleeding

Aim

To evaluate the feasibility and safety of implementing a restrictive versus liberal red blood cell (RBC) transfusion policy in adult patients admitted with Acute Upper Gastrointestinal Bleeding (AUGIB) in order to inform the design of a definitive phase III randomised controlled trial.

Trial Design

A multi-centre, feasibility, cluster randomised controlled trial comparing restrictive versus liberal blood transfusion strategies in adult patients admitted with acute upper gastrointestinal bleeding

Chief Investigator

Professor Mike Murphy & Dr, Vipul Jairath 

Local PI

Professor Alasdair Gray

List of Publications – References

Vipul Jairath, Brennan C Kahan, Alasdair Gray, Caroline J Doré, Ana Mora, Martin W James, Adrian J Stanley, Simon M Everett, Adam A Bailey, Helen Dallal, John Greenaway, Ivan Le Jeune, Melanie Darwent, Nicholas Church, Ian Reckless, Renate Hodge, Claire Dyer, Sarah Meredith, Charlotte Llewelyn, Kelvin R Palmer, Richard F Logan, Simon P Travis, Timothy S Walsh, Michael F Murphy: Restrictive versus liberal blood transfusion for acute uppergastrointestinal bleeding (TRIGGER): a pragmatic, open-label,cluster randomised feasibility trial. The Lancet Published online May 6, 2015