Toggle menu

First “First Responder” Study

Start date:
February 2016
End date:
May 2017
Co-ordinated by:
EMERGE-RRG team on behalf of University of Edinburgh (
Main trial site:

R&D Ref. 2015/0342
REC Ref. 15/SS/0128

Research to date is very clear that quick action is essential to improving the probability of survival and good brain function following OHCA. Even brief delays in calling for help or beginning CPR can have a profound impact on whether resuscitation is successful or not. For every minute that a defibrillatory shock is delayed after the onset of a shockable cardiac rhythm, the survival rate decreases by 7-10% (Holmberg et al. 2000, Larsen et al. 1993). Performing CPR during this interval slows the rate of survival decline to just 3-4% per minute, allowing emergency services to get to the scene while the patient is still salvageable (Laren et al. 1993; Valenzuela et al. 1997). Empirical evidence from multiple studies suggests that bystander CPR increases the OHCA victim’s chance of survival by between 2 and 3 times (Lloyd-Jones, et al., 2009) and bystander CPR is cited as a major factor in the success of centres with the world’s best OHCA survival rates (Kellermann 2010).

Despite the bystander responder’s critical role in summoning and delivering help to the victim, almost no information exists as to how the bystander makes crucial decisions, such as when to call emergency services, or whether to begin CPR. Similarly, the impact of such an experience on the subsequent well-being of the bystander, and what support may be helpful or necessary for them, has not been evaluated.

This study aims to provide the first in-depth look into the experience of the OHCA bystander responder. These insights will allow us to look for ways we can improve the early steps in the “chain of survival” following OHCA — the steps often most likely to bring about the biggest improvements in patient survival and function after a cardiac arrest. Information about how we could deliver care to OHCA victims better and faster, before professional help has arrived, can be used to inform public education efforts, aspects of public policy, and emergency medical systems design. Further, this research investigates the emotional impact of participating in OHCA for the bystander who responds, directing much delayed attention to their emotional responses and well-being.

Research goals: To provide the first in-depth understanding of the non-medical person’s experience responding to an OHCA, allowing exploration of two main objectives: 1) identifying ways in which initial prehospital care of the OHCA patient might be improved, and 2) identifying the risks and benefits of involvement in OHCA response for non-medical persons, and how that experience might be made easier for those respond.


For more information please contact the study team on 0131 242 9352.

Chief Investigator

Dr Gareth Clegg

Senior Lecturer at the University of Edinburgh & Honorary Consultant in Emergency Medicine

Local PI

Dr Christine Houser

'First First Responder' Project Lead

Research Team

Joel Symonds

Research Paramedic

Emma Ward

Research Administrator

Miranda Odam

Research Nurse Manager

Related news

The Scottish Cardiac Arrest Symposium 2016 – Register now!

The Scottish Cardiac Arrest Symposium 2016 – Register now!

29 Mar 2016 | Lisa MacInnes


Read more
Save A Life for Scotland

Save A Life for Scotland

9 Oct 2015 | Dr Alistair Dewar

Read more

More EMERGE Trials

TARGET CTCA is a joint venture between EMERGE and the cardiology research team aiming to recruit patients with suspected ACS across NHS Lothian and NHS Greater Glasgow and Clyde. The study aims to recruit 2270 participants. For further information, please contact the EMERGE team.

Read more


Diagnostics devices play an important part in the clinical assessment of a patient’s health and treatment. The purpose of the study is the evaluation of a new diagnostic platform developed by LumiraDx. The evaluation is focused around various biomarkers useful in the emergency settings.

Read more


Collection of venous and capillary blood samples for the evaluation of new diagnostic devices for cardiovascular conditions

Identification and characterization of the clinical toxicology of novel psychoactive substances (NPS) by laboratory analysis of biological samples from recreational drug users.

Read more

IONA Study

Identification of Novel Psychoactive Substances (IONA)