The DAShED (Diagnosis of Acute Aortic Syndrome in the ED) study: An observational cohort study of people attending the ED with symptoms consistent of Acute Aortic syndrome (AAS)
Acute aortic syndrome (AAS) is a life-threatening emergency condition affecting the upper aorta affecting ~4000 people in the UK a year with an ED misdiagnosis rate as high as 38%.
Previous research has identified several strategies combining clinical probability scoring with blood tests (D-Dimer) to rule out the condition but when applied to a large population (ED) with relatively low numbers of actual cases, these result in a high rate of computed tomographic angiography (CTA) scanning. Current guidelines reflect the uncertainty of existing evidence.
This study, the first phase of three (we are seeking funding from RCEM for phase 1 only) aims to describe the characteristics of ED attendances with possible AAS, to determine the service implications of using different diagnostic strategies and inform future research
We plan to recruit all ED attendances with possible AAS in at least 5 EDs over a 4-week period. We plan a prospective and retrospective approach to data collection adopting a zero-consent strategy with endpoint measures describing the characteristics of patients presenting with possible AAS.
We were delighted to learn in April 2022, that DAShED received funding from RCEM
Study draft paperwork
Preliminary published work: