A BRitish feasibility study of molecular stratification and targeted therapy to optimize the clinical mAnagement of patIeNts with glioMA by enhancing clinical ouTcomes, Reducing avoIdable toXicity, improving management of post-operative residual & recurrent disease and improving survivorship

A BRitish feasibility study of molecular stratification and targeted therapy to optimize the clinical mAnagement of patIeNts with glioMA by enhancing clinical ouTcomes, Reducing avoidable toXicity, improving management of post-operative residual & recurrent disease and improving survivorship

The Tessa Jowell BRAIN MATRIX study will be the first collaboration between the EMERGE neurosurgery team and the oncology research nurses in the Western General Hospital. The central trial team are the Cancer Research UK Clinical Trials Unit at the University of Birmingham and the local PI in Edinburgh will be Mr. Paul Brennan, Consultant Neurosurgeon.

This is an observational study exploring biomarkers in patients undergoing neurosurgery for gliomas. It aims improve knowledge of gliomas and to optimise the clinical management and subsequent outcomes of these patients.

Along with cognitive testing and quality-of-life questionnaires, the study will involve the collection of blood and tumour samples and will follow participants from pre-operation throughout their oncology journey and up to subsequent surgeries if applicable.