ATTEST2 Trial
Start date:July 2017 End date:
January 2021 Co-ordinated by:
The Stroke Research Team Main trial site:
NHS Greater Glasgow & Clyde
ATTEST 2 aims to test tenecteplase in a large clinical trial to establish whether it is a better drug than alteplase for use in thrombolysis. This will involve a large number of hospitals in the UK, and possibly overseas. People who are considered suitable for thrombolysis will be allocated at random to receive either the current standard treatment with alteplase, or tenecteplase, and will be followed up for the first 90 days to measure the effects on recovery.
Even if there are no significant differences between between the two drugs, tenecteplase is less expensive and much easier to give to patients than alteplase, needing a single injection only. Alteplase has to be given as an injection followed by a longer injection over an hour. This advantage of tenecteplase alone would have worthwhile benefits to the patient.
Trial Design
Prospective Randomised Open, Blinded End-point (PROBE) – Phase III
Principal Investigator
Dr. Will Whitely, Stroke Medicine, University of Edinburgh & NHS Lothian
Chief Investigator
Dr William Whitely
Scottish Senior Clinical Fellow and Consultant Neurologist
Local PI
Dr Matt Reed
Director of EMERGE, Consultant, NRS Career Research Fellow & Honorary Reader in Emergency Medicine
Research Team
Rachel O'Brien
Lead Research Nurse
Allan MacRaild
Stroke Lead Research Nurse
Polly Black
Senior Research Nurse
Caroline Blackstock
AMU Senior Research Nurse
Alison Williams
Senior Research Nurse
Fiona McCurrach
Senior Research Nurse
Seona Burgess
Senior Stroke Research Nurse
Jessica Teasdale
Senior Research Nurse - Stroke/Neurosurgery
Michelle Curtin
Senior Research Nurse - Stroke/Neurosurgery
Fiona McCurrach
Senior Research Nurse
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