Below are details of all current trials at EMERGE. Either click the area you are interested to see relevant studies or scroll through all our work.

If there is a study you’re interested in that isn’t listed here or you’d like to discuss a study with us then please get in touch. If you’re interested in a commercial collaboration and EMERGE evaluating something for you the please visit our Commercial Collaboration page.

Cardiovascular

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	ASPIRED	Multi-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients	British Heart Foundation	Dr Matt Reed	Nicky Freeman	Opening Feb 2022
ACUTE	ACUTE	A mechanistic study of intravenous thiamine for acute heart failure	Medical Research Council	Professor Michael Eddleston&Dr Matt Reed	Caroline Blackstock	Open to Recruitment
	TARGET-CTCA Trial	Troponin in Acute chest pain to Risk stratify and Guide EffecTive use of Computed Tomography Coronary Angiography	British Heart Foundation	Professor Nick Mills	Rachel O’Brien	Open to Recruitment
	IPED implementation study	Real-world clinical implementation of a smartphone-based event recorder in the ED for patients with palpitation	n/a	Dr Matt Reed	Dr Julia Cullen	In write up stage

Stroke and Neurosurgery

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	ATTEST2 Trial	Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis	Stroke Association & British Heart Foundation	Dr William Whitely	Jessica Teasdale	Open to Recruitment
AXIOMATIC-SSP	AXIOMATIC-SSP	Antithrombotic treatment with factor XIa inhibition to Optimize Management of Acute Thromboembolic events in Secondary Stroke Prevention	Bristol-Myers Squibb	Dr Neil Hunter	Michelle Coakley	Open to Recruitment
	BRAIN MATRIX	A BRitish feasibility study of molecular stratification and targeted therapy to optimize the clinical mAnagement of patieNts with glioMA by enhancing clinical ouTcomes, Reducing avoidable toXicity, improving management of post-operative residual & recurrent disease and improving survivorship	The Brain Tumour Charity and Genomics England	Dr Paul Brennan	Michelle Coakley	In Set Up
BRAINED- TBI	BRAINED – TBI	Using Fourier Transform Infrared Spectrotroscopy for Earlier Diagnosis and Rapid Stratification of Patients with a Traumatic Brain Injury	NIHR Brain Injury MedTech Co-operative Seedcorn Funding Competition	Dr Paul Brennan/	Polly Black	Open to Recruitment
	DASH Trial	DASH is a randomised clinical trial investigating a treatment to reverse the effects of blood-thinning medications.	NIHR	Professor Rustam Al-Shahi Salman	Michelle Coakley	Open to Recruitment
	DENS	Duration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collar	NIHR HTA	Dr Paul Brennan/Dr Matt Reed	Polly Black	In Set Up
ENRICH-AF	ENRICH-AF	EdoxabaN foR IntraCranial Hemorrhage survivors with Atrial Fibrillation	Daiichi Sankyo Company	Professor Rustam Al-Shahi Salman	Seona Burgess	Open to Recruitment
	HeadOn Study	Delivery of digital cognitive behaviour therpy following concusion: HeadOn Feasibility Study	NIHR Brain Injury, MedTech Co-operative, Seedcorn Funding Competition	Aimun Jamjoom/Dr Matt Reed	Alison Grant	In Set Up
	INFERENCE	IdentificatioN oF biomarkErs foR Early diagNosis of CancEr	Innovate UK	Dr Paul Brennan	Polly Black	Open to Recruitment
	Laci-2	Assessment of safety and efficacy of cilostazol and isosorbide mononitrate to prevent recurrent lacunar stroke and progression of cerebral small vessel disease	British Heart Foundation	Professor Joanna Wardlaw	Allan MacRaild	Open to Recruitment
	LINCH-PIN	Lothian study of INtraCerebral Haemorrhage Pathology, Imaging & Neurological outcome	UK Medical Research Council and The Stroke Association	Dr Neshika Samarasekera	Seona Burgess	Open to Recruitment
	OPTIMAS	OPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trial	British Heart Foundation	Dr Fergus Dougal	Jessica Teasdale	In Set Up
	PRECIOUS	A clinical trial to look at PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke	European Union’s Horizon 2020 Research and Innovation Programme	Professor Malcolm MacLeod	Seona Burgess	Open to Recruitment
	R4VAD	Rates, Risks and Routes to Reduce Vascular Dementia	Stroke Association, Alzheimer’s Society, and British Heart Foundation	Professor Joanna Wardlaw	Rachel Sutherland	Open to Recruitment
Shared Stroke Decisions	Shared Stroke Decisions	Development and implementation of Realistic Medicine for severe stroke through Shared Decision Making	Edinburgh and Lothian Health Foundation	Professor Gillian Mead	Polly Black	In Set Up
	TRIDENT	Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial	National Health and Medical Research Council (NHMRC) of Australia	Dr Neshika Samarasekera	Seona Burgess	Open to Recruitment

Toxicology

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
IONA	IONA	Identification Of Novel psychoActive substances	NIHR portfolio	Professor Michael Eddleston	Caroline Blackstock	Open to Recruitment
	MAPP2 Study	The Markers and Paracetamol Poisoning Study 2	Rosetrees Trust and Kidney Research UK	Professor James Dear	Caroline Blackstock	Open to Recruitment
POP2	POP2	A Randomised, Double-blind, Placebo-Controlled, Phase 2/3 Study with 2 Doses of Calmangafodipir in Increased Risk Patients Treated with N Acetylcysteine for Acetaminophen/Paracetamol Overdose	Egetis Therapeutics	Professor James Dear	Julia Grahamslaw/Caroline Blackstock	In Set Up

Blood Project Group

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	National Code Red Audit	The aim of this audit is to monitor and optimise the transfusion support given to patients following major trauma in Scotland.	SNBTS	Dr Matt Reed	Dr Matt Reed	Open
	Rotem in ED	Single centre, prospective, observational Emergency Department based study of trauma patients who undergo ROTEM testing	RCEM	Dr Matt Reed	Dr Matt Reed	Open

COVID-19

Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
FALCON	Facilitating AcceLerated Clinical evaluation Of Novel diagnostic tests for COVID-19	NIHR, Asthma UK & British Lung Foundation	Dr Rachel McLatchie	Caroline Blackstock	Open to Recruitment
ISARIC4C	Clinical Characterisation Protocol for Severe Emerging Infections in the UK	MRC, Wellcome Trust, SPRINT-SARI NIHR Health Protection Research Unit (HPRU) in Respiratory Infection, HPRU in Emerging and Zoonotic Infections	Dr Kenneth Baillie	Caroline Blackstock	Open to Recruitment
RECOVERY Trial	Randomised Evaluation of COVID-19 Therapy	UK Research and Innovation/National Institute for Health Research (NIHR) and the Wellcome Trust	Professor Alasdair Gray	Allan MacRaild	Open to Recruitment
SIREN	The impact of detectable anti SARS-COV2 antibody on the incidence of COVID-19 in healthcare workers	Department of Health and Social Care	Dr Kate Templeton	Emily Godden	Completing Follow Up

Sepsis

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	ABC SEPSIS	Feasibility of 5% Albumin compared with Balanced Crystalloid, as intravenous fluid resuscitation in adult patients with sepsis, presenting as an emergency to hospital	The Jon Moulton Charity Trust	Professor Alasdair Gray	Julia Grahamslaw	Open to recruitment
	MIS-ABC Sepsis	Mechanistic Inflammatory Sub-study.	The Royal College of Emergency Medicine.	Jack Cafferkey	Julia Grahamslaw	In set up

Renal

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
AFiRM	AFiRM	Application of Functional Renal MRI to improve assessment of chronic kidney disease	National Institute for Health Research	Dr Neeraj Dhaun	Emily Godden	In Set Up
	KRAKIL Study	Kidney Recovery after Acute Kidney Injury – Longitudinal study	Medical Research Council	Professor James Dear	Emily Godden	Open to Recruitment
OCT	OCT	Assessment of retinal vasculature using optical coherence tomography in health, hypertension & kidney disease		Dr Neeraj Dhaun	Emily Godden	Open to Recruitment

Trauma, Surgical and Orthopaedics

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	PROM OCTS	The creation and field testing of a new rib fracture specific patient reported outcome measure	AOUK&I/NIHR HTA ORiF	Dr Matt Reed	Nicky Freeman	Completing Follow Up

Paediatrics

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status

Other

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status

Innovation Studies

Biomarker

Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
EMBOL1 Study	A Performance Evaluation of The LumiraDX Point of Care D-DIMER Assay	LumiraDX	Professor Alasdair Gray	Julia Grahamslaw	In Set Up
NOVEL Study	Collection of Venous and Capillary Blood Samples for the Development of New Diagnostic Devices for Cardiovascular Conditions	LumiraDX	Professor Alasdair Gray	Nicky Freeman	Open for Recruitment
REACT Study	A Performance Evaluation of The LumiraDX Point of Care CRP Assay	LumiraDX	Professor Alasdair Gray		In Set Up

Medical Wearable Device studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
ASPIRED	ASPIRED	Multi-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients	British Heart Foundation	Dr Matt Reed	Nicky Freeman	In Set Up

Data Projects

Data Science

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	Improving Multi-Morbidity Acute Care Using Data Analytics	SBRI: Improving Multi-Morbidity Acute Care Using Data Analytics	Health Innovation South East Scotland / Innovate UK	Naz Lone/Dr Matt Reed	Dr Matt Reed	Ongoing
	Improving Care through Data Driven Innovation	Multimorbidity and Emergency Healthcare Provision: Improving Care through Data Driven Innovation	Wellcome Trust ISSF3	Naz Lone/Dr Matt Reed	Dr Matt Reed	Ongoing

Curious? If you'd like to know more about our work then please get in touch. Contact us

Current Research

Clinical Research

Innovation

Data projects