Below are details of all current trials at EMERGE. Either click the area you are interested to see relevant studies or scroll through all our work.
If there is a study you’re interested in that isn’t listed here or you’d like to discuss a study with us then please get in touch. If you’re interested in a commercial collaboration and EMERGE evaluating something for you the please visit our Commercial Collaboration page.
Cardiovascular
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
ASPIRED | Multi-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients | British Heart Foundation | Professor Matt Reed | Caroline Blackstock | Open to Recruitment | |
POC-ET | Point of Care Evaluation of high-sensitivity cardiac Troponin (POC-ET) study | British Heart Foundation | Professor Nick Mills | Fiona McCurrach | Open to Recruitment | |
TARGET-CTCA Trial | Troponin in Acute chest pain to Risk stratify and Guide EffecTive use of Computed Tomography Coronary Angiography | British Heart Foundation | Professor Nick Mills | Rachel O’Brien | Closed - in analysis stage |
Stroke and Neurosurgery
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
ATTEST2 Trial | Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis | Stroke Association & British Heart Foundation | Dr William Whitely | Allan MacRaild | Open to Recruitment | |
BRAIN MATRIX | A BRitish feasibility study of molecular stratification and targeted therapy to optimize the clinical mAnagement of patieNts with glioMA by enhancing clinical ouTcomes, Reducing avoidable toXicity, improving management of post-operative residual & recurrent disease and improving survivorship | The Brain Tumour Charity and Genomics England | Dr Paul Brennan | Allan MacRaild | Open to Recruitment | |
BRAINED- TBI | BRAINED – TBI | Using Fourier Transform Infrared Spectrotroscopy for Earlier Diagnosis and Rapid Stratification of Patients with a Traumatic Brain Injury | NIHR Brain Injury MedTech Co-operative Seedcorn Funding Competition | Dr Paul Brennan | Sarah Risbridger | Completing Follow Up |
Can-SCAHn | Can-SCAHn | Selective neuroimaging for head-injured emergency patients who take anticoagulant medication. | Canadian Institutes of Health Research | Professor Matt Reed | Julia Grahamslaw | In Set Up |
CARE | Cavernomas A Randomised Effectiveness (CARE) pilot trial, to address the effectiveness of active treatment (with neurosurgery or stereotactic radiosurgery) versus conservative management in people with symptomatic brain cavernoma | NIHR | Mr Ioannis Fouyas | Allan MacRaild | Open to Recruitment | |
DENS | Duration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collar | NIHR HTA | Dr Paul Brennan/Professor Matt Reed | Anuka Boldbaatar | Open to Recruitment | |
ENRICH-AF | ENRICH-AF | EdoxabaN foR IntraCranial Hemorrhage survivors with Atrial Fibrillation | Daiichi Sankyo Company | Professor Rustam Al-Shahi Salman | Anuka Boldbaatar | Open to Recruitment |
IMPACT | International Post Market Product Surveillance Study of Intracranial Aneurysms Treated with an Endovascular Approach | STRYKER | Dr Jonny Downer | Allan MacRaild | Open to Recruitment | |
INFERENCE | IdentificatioN oF biomarkErs foR Early diagNosis of CancEr | Innovate UK | Dr Paul Brennan | Sarah Risbridger | Completing Follow Up | |
OPTIMAS | OPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trial | British Heart Foundation | Dr Fergus Dougal | Sarah Risbridger | Open to Recruitment | |
PreSize | Real-World Performance Evaluation of PreSize Neurovascular Medical Software in a Clinical Setting | Oxford Heartbeat | Dr Jonny Downer | Sarah Risbridger | Open to Recruitment | |
PROHIBIT-ICH | Prevention Of Hypertensive Injury to the Brain by Intensive Treatment after IntraCerebral Haemorrhage: a pilot randomised trial of home telemetry-guidedtreatment | Stroke Association | Neshika Samarasekera | Allan MacRaild | Completing Follow Up | |
SEALANT | SEALANT: Safety and Effectiveness Analysis of stent assisted coiling with LVIS® Evo™ and HydroCoil® Embolic System in ANeurysm Treatment | Microvention | Dr Jonny Downer | Anuka Boldbaatar | Open to Recruitment | |
Shared Stroke Decisions | Shared Stroke Decisions | Development and implementation of Realistic Medicine for severe stroke through Shared Decision Making | Edinburgh and Lothian Health Foundation | Professor Gillian Mead | Sarah Risbridger | Completing Follow Up |
TREAT | Trenza Embolization Device for Intrasaccular Aneurysm Treatment | STRYKER | Dr Jonny Downer | Allan MacRaild | Open to Recruitment | |
TRIDENT | Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial | Neshika Samarasekera | Allan MacRaild | Open to Recruitment | ||
PhEAST | Pharyngeal Electrical stimulation for Acute Stroke dysphagia Trial | National Institute of Health Research Health Technology Assessment program Devices supplied by Phagenesis Ltd | Richard O’Brien | Sarah Risbridger | Open to Recruitment | |
Oceanic Stroke | Phase 3 study to investigate the efficacy and safety of the oral FXIa inhibitor asundexian (BAY 2433334) compared with placebo in participants after an acute non-cardioembolic ischemic stroke or high-risk TIA | Bayer AG | Neil Hunter | Sarah Risbridger | Open to Recruitment | |
BRAINED3 | BRAINED3 | Assessing the performance of Infrared blood-based spectroscopy technology and its ability to identify patients suffering from non-specific symptoms who have a brain cancer. | Dr Paul Brennan | Shona McDonald | Open for Recruitment |
Toxicology
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
POP2 | POP2 | A Randomised, Double-blind, Placebo-Controlled, Phase 2/3 Study with 2 Doses of Calmangafodipir in Increased Risk Patients Treated with N Acetylcysteine for Acetaminophen/Paracetamol Overdose | Egetis Therapeutics | Professor James Dear | Julia Grahamslaw/Caroline Blackstock | In Set Up |
HiSNAP | The HiSNAP Trial aims to test conventional (200mg/kg) versus higher (450mg/kg and 600mg/kg) doses of the drug N-Acetylcysteine (known as NAC) which is commonly used to treat the effects of paracetamol overdose | Chief Scientist Office | Professor James Dear | Anna Miell | Open to Recruitment | |
POC-DILI | POC-DILI | The Point-of-care Assessment of Drug-Induced Liver Injury (POC-DILI) Study aims to develop blood testing for liver injury during the early stages of assessment of people who have taken a paracetamol overdose. | Medical Research Council (MRC) | Professor James Dear | Anna Miell | In Set Up |
TIPSS | TIPSS | This trial aims to determine where in the body sulbutiamine/benfotiamine is converted to thiamine. | Medical Research Council (MRC) (Confidence in Concept Fund) | Professor Michael Eddleston | Anna Miell | Closed |
Thiamine in CSF | Thiamine in CSF | This study aims to compare several forms of thiamine by testing the absorption into the blood and cerebrospinal fluid (CSF) at different time points after taking a dose | Professor Michael Eddleston | Anna Miell | Open to Recruitment |
Blood Project Group
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
National Code Red Audit | The aim of this audit is to monitor and optimise the transfusion support given to patients following major trauma in Scotland. | SNBTS | Professor Matt Reed | Professor Matt Reed | Open to Recruitment |
Sepsis
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
EVIS | Early Vasopressors in Sepsis | Dr. Alasdair Corfield | Julia Grahamslaw &Fiona McCurrach | Open to Recruitment |
Renal
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
KRAKIL Study | Kidney Recovery after Acute Kidney Injury – Longitudinal study | Medical Research Council | Professor James Dear | Beth Morrison | Closed to Recruitment | |
AFiRM | AFiRM | Application of Functional Renal MRI to improve assessment of chronic kidney disease | National Institute for Health Research | Professor 'Bean' Neeraj Dhaun | Beth Morrison | Closed to Recruitment |
OCT | OCT | Assessment of retinal vasculature using optical coherence tomography in health, hypertension & kidney disease | Professor 'Bean' Neeraj Dhaun | Beth Morrison | Open to Recruitment | |
CRAFT-CTCA | CRAFT-CTCA | Observational study in patients with kidney failure who are on the waitlist for a kidney transplant. | Professor 'Bean' Neeraj Dhaun | Beth Morrison | Open to Recruitment | |
Spartan | Spartan | Investigating sparsentan treatment in renin angiotensin system (RAS) blockade-naïve patients with biopsy-proven immunoglobulin A nephropathy (IgAN). | Professor 'Bean' Neeraj Dhaun | Beth Morrison | Closed to Recruitment | |
SPARVASC | SPARVASC | SPARsentan treatment in VASCulitis - Endothelin receptor antagonism to reduce cardiovascular risk in ANCA-associated vasculitis. | University of Edinburgh & (collaborator) Travere Therapeutics, Inc. | Professor 'Bean' Neeraj Dhaun | Beth Morrison | Open to Recruitment |
Trauma, Surgical and Orthopaedics
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
RELIEF | The Randomised Evaluation of early topical Lidocaine patches In Elderly patients admitted to hospital with rib Fractures (RELIEF): feasibility trial | North Bristol NHS Trust | Dr. Edward Carlton | Fiona McCurrach | Completing Follow Up | |
RACER | RACER | Robotic Arthroplasty: a Clinical and cost Effectiveness Randomised controlled trial | Ms Chloe Scott | Victoria Minnis | Open to Recruitment | |
Paediatrics
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
FIDO | Validating clinical decision aids for the assessment and management of febrile infants presenting to emergency care in the UK and Ireland. | Royal College of Emergency Medicine Doctoral Fellowship | Dr Thomas Waterfield | Ashleigh Hegan | Closed to Recruitment | |
MAST | Pharmacological Management of Seizures post Traumatic Brain Injury. | NIHR | Dr Jay Shetty | Ashleigh Hegan | Open to recruitment | |
BACHb | Breathing Assistance in CHildren with bronchiolitis (BACHb): a group-sequential two-stratum multicentre open-label randomised clinical trial of respiratory support in infants with acute bronchiolitis | National Institute of Health Research | Dr David Armstrong | Caroline Blackstock | In Set Up |
Other
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
CoSTED | Cessation Of Smoking Trial in the Emergency Department | Norfolk and Norwich University Hospitals NHS Foundation Trust (NNUH) | Professor Alasdair Gray | Anna Miell | Closed | |
RECOVERY Trial | RECOVERY is an international clinical trial identifying treatments that be beneficial for people hospitalised with pneumonia | NIHR Oxford Biomedical Research Centre, the Wellcome Trust | Professor Alasdair Gray | Rachel O’Brien | Open to Recruitment | |
POS-ARI-ER | POS-ARI-ER | The POS-ARI-ER study is a multicentre, Perpetual Observational Study of patients with suspected Acute Respiratory Infections presenting via Emergency Rooms and other acute hospital care settings. | Dr Jon Carter | Shona McDonald | Open to Recruitment | |
FORCE:SEE | FORCE:SEE | Frailty and Outcomes Record in Clinical Environments: probable Sarcopenia, geriatric Evaluation, and Events | Dr Alixe Kilgour | Victoria Minnis | Open to Recruitment | |
CoMiTED | Conservative Management in Traumatic Pneumothoraces in the Emergency Department (CoMiTED) | NIHR-HTA | Professor Edward Carlton/Dr Lyle Moncur | Caroline Blackstock | Open to Recruitment | |
CONSEPT | Conservative versus Standard care for primary spontaneous Pneumothorax (CONSEPT) | North Bristol NHS Trust Research & Innovation | Dr Marie-Clare Harris | Alison Grant | Open to Recruitment | |
Macrophage Therapy For Acute Liver Injury (MAIL) Trial: A Phase 1 Randomised, Blinded, Dose-Escalation Study to Evaluate Safety, Tolerability, and Activity of Allogeneic Alternatively Activated Macrophages (AAM) in Patients with Paracetamol-induced Acute Liver Injury. | Professor James Dear | Alison Grant | Open to Recruitment |
Innovation Studies
Biomarker
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
NOVEL2 Study | Collection of Venous and Capillary Blood Samples for the Development of New Diagnostic Devices for Cardiovascular Conditions | LumiraDX | Professor Alasdair Gray | Victoria Minnis | Open for Recruitment | |
PERFORM-TSIX | Clinical Performance of Elecsys® Troponin T hs Gen 6 in Subjects with Symptoms of Acute Coronary Syndrome. The purpose of this research study is to evaluate the performance of the investigational diagnostic test which may help doctors diagnose heart attacks faster and more accurately than they can today. | Roche | Professor Richard Body/ Dr Stephen Lynch | Caroline Blackstock | Open for Recruitment |
Medical Wearable Device studies
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
ASPIRED | Multi-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients | British Heart Foundation | Professor Matt Reed | Caroline Blackstock | Open to Recruitment |
Data Projects
Data Science
Logo | Title | Description | Funding Body | Chief/Principal Investigator | Key Contact | Status |
---|---|---|---|---|---|---|
Improving Multi-Morbidity Acute Care Using Data Analytics | SBRI: Improving Multi-Morbidity Acute Care Using Data Analytics | Health Innovation South East Scotland / Innovate UK | Naz Lone/Professor Matt Reed | Professor Matt Reed | Ongoing | |
Improving Care through Data Driven Innovation | Multimorbidity and Emergency Healthcare Provision: Improving Care through Data Driven Innovation | Wellcome Trust ISSF3 | Naz Lone/Professor Matt Reed | Professor Matt Reed | Ongoing | |
EMERGE Biobank | A project to develop a prospective, consecutive, emergency, bio resource for emergency presentations | n/a | Professor Matt Reed | Professor Matt Reed | Ongoing |