Below are details of all current trials at EMERGE. Either click the area you are interested to see relevant studies or scroll through all our work.

If there is a study you’re interested in that isn’t listed here or you’d like to discuss a study with us then please get in touch. If you’re interested in a commercial collaboration and EMERGE evaluating something for you the please visit our Commercial Collaboration page.

Cardiovascular

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ACUTEACUTEA mechanistic study of intravenous thiamine for acute heart failureMedical Research CouncilProfessor Michael Eddleston&Dr Matt ReedCaroline BlackstockOpen to Recruitment
TARGET-CTCA TrialTroponin in Acute chest pain to Risk stratify and Guide EffecTive use of Computed Tomography Coronary Angiography British Heart FoundationProfessor Nick MillsRachel O’BrienOpen to Recruitment
IPED implementation studyReal-world clinical implementation of a smartphone-based event recorder in the ED for patients with palpitationn/aDr Matt ReedDr Julia CullenIn write up stage

Stroke and Neurosurgery

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ATTEST2 TrialAlteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis Stroke Association & British Heart FoundationDr William WhitelyJessica TeasdaleOpen to Recruitment
AXIOMATIC-SSPAXIOMATIC-SSPAntithrombotic treatment with factor XIa inhibition to Optimize Management of Acute
Thromboembolic events in Secondary Stroke Prevention
Bristol-Myers SquibbDr Neil HunterMichelle CoakleyOpen to Recruitment
BRAIN MATRIXA BRitish feasibility study of molecular stratification and targeted therapy to optimize the clinical mAnagement of patieNts with glioMA by enhancing clinical ouTcomes, Reducing avoidable toXicity, improving management of post-operative residual & recurrent disease and improving survivorshipThe Brain Tumour Charity and Genomics EnglandDr Paul BrennanMichelle CoakleyIn Set Up
BRAINED- TBIBRAINED – TBIUsing Fourier Transform Infrared Spectrotroscopy for Earlier Diagnosis and Rapid Stratification of Patients with a Traumatic Brain InjuryNIHR Brain Injury MedTech Co-operative Seedcorn Funding CompetitionDr Paul Brennan/Polly BlackOpen to Recruitment
DASH TrialDASH is a randomised clinical trial investigating a treatment to reverse the effects of blood-thinning medications.NIHRProfessor Rustam Al-Shahi SalmanMichelle CoakleyOpen to Recruitment
DENSDENSDuration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collarNIHR HTADr Paul Brennan/Dr Matt ReedPolly BlackIn Set Up
ENRICH-AFENRICH-AFEdoxabaN foR IntraCranial Hemorrhage survivors with Atrial FibrillationDaiichi Sankyo
Company
Professor Rustam Al-Shahi SalmanSeona BurgessOpen to Recruitment
HeadOn StudyDelivery of digital cognitive behaviour therpy following concusion: HeadOn Feasibility StudyNIHR Brain Injury, MedTech Co-operative, Seedcorn Funding CompetitionAimun Jamjoom/Dr Matt ReedAlison GrantIn Set Up
INFERENCEIdentificatioN oF biomarkErs foR Early diagNosis of CancErInnovate UKDr Paul BrennanPolly BlackOpen to Recruitment
Laci-2Assessment of safety and efficacy of cilostazol and isosorbide mononitrate to
prevent recurrent lacunar stroke and progression of
cerebral small vessel disease
British Heart FoundationProfessor Joanna Wardlaw Allan MacRaildOpen to Recruitment
LINCH-PINLothian study of INtraCerebral Haemorrhage Pathology,
Imaging & Neurological outcome
UK Medical Research
Council and The Stroke Association
Dr Neshika SamarasekeraSeona BurgessOpen to Recruitment
OPTIMASOPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trialBritish Heart FoundationDr Fergus DougalJessica TeasdaleIn Set Up
PRECIOUSA clinical trial to look at PREvention of Complications to
Improve OUtcome in elderly patients with acute Stroke
European Union’s Horizon 2020 Research and Innovation
Programme
Professor Malcolm MacLeodSeona BurgessOpen to Recruitment
R4VADRates, Risks and Routes to Reduce Vascular DementiaStroke Association, Alzheimer’s Society, and British Heart
Foundation
Professor Joanna WardlawRachel SutherlandOpen to Recruitment
Shared Stroke DecisionsShared Stroke DecisionsDevelopment and implementation of Realistic Medicine for severe stroke through Shared Decision MakingEdinburgh and Lothian Health FoundationProfessor Gillian MeadPolly BlackIn Set Up
TRIDENTTriple therapy prevention of Recurrent Intracerebral Disease EveNts TrialNational Health and Medical Research
Council (NHMRC) of Australia
Dr Neshika SamarasekeraSeona BurgessOpen to Recruitment

Toxicology

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
IONAIONAIdentification Of Novel psychoActive substances NIHR portfolioProfessor Michael EddlestonCaroline BlackstockOpen to Recruitment
MAPP2 StudyThe Markers and Paracetamol Poisoning Study 2Rosetrees Trust and Kidney Research UKProfessor James DearCaroline BlackstockOpen to Recruitment
POP2POP2A Randomised, Double-blind, Placebo-Controlled, Phase 2/3 Study with 2 Doses of Calmangafodipir in Increased Risk Patients Treated with N Acetylcysteine for Acetaminophen/Paracetamol OverdoseEgetis Therapeutics Professor James DearJulia Grahamslaw/Caroline BlackstockIn Set Up

Blood Project Group

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
National Code Red AuditThe aim of this audit is to monitor and optimise the transfusion support given to patients following major trauma in Scotland.SNBTSDr Matt ReedDr Matt ReedOpen
Rotem in EDSingle centre, prospective, observational Emergency Department based study of trauma patients who undergo ROTEM testingRCEMDr Matt ReedDr Matt ReedOpen

COVID-19

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
FALCONFacilitating AcceLerated Clinical evaluation Of Novel diagnostic tests for COVID-19NIHR, Asthma UK & British Lung FoundationDr Rachel McLatchieCaroline BlackstockOpen to Recruitment
ISARIC4CClinical Characterisation Protocol for Severe Emerging
Infections in the UK
MRC, Wellcome Trust,
SPRINT-SARI NIHR Health Protection Research Unit (HPRU) in Respiratory Infection, HPRU
in Emerging and Zoonotic Infections
Dr Kenneth BaillieCaroline BlackstockOpen to Recruitment
RECOVERY TrialRandomised Evaluation of COVID-19 TherapyUK Research and
Innovation/National Institute for Health Research (NIHR) and the Wellcome Trust
Professor Alasdair GrayAllan MacRaildOpen to Recruitment
SIRENThe impact of detectable anti SARS-COV2 antibody on the incidence of COVID-19 in healthcare workersDepartment of Health and Social CareDr Kate TempletonEmily GoddenCompleting Follow Up

Sepsis

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ABC SEPSISFeasibility of 5% Albumin compared with Balanced Crystalloid, as intravenous
fluid resuscitation in adult patients with sepsis, presenting as an emergency to
hospital
The Jon Moulton Charity Trust
Professor Alasdair GrayJulia GrahamslawOpen to recruitment
MIS-ABC SepsisMechanistic Inflammatory Sub-study. The Royal College of Emergency Medicine.Jack CafferkeyJulia GrahamslawIn set up

Renal

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
AFiRMAFiRMApplication of Functional Renal MRI to improve assessment of chronic kidney diseaseNational Institute for Health ResearchDr Neeraj DhaunEmily GoddenIn Set Up
KRAKIL StudyKidney Recovery after Acute Kidney Injury – Longitudinal studyMedical Research CouncilProfessor James DearEmily GoddenOpen to Recruitment
OCTOCTAssessment of retinal vasculature using optical coherence tomography in
health, hypertension & kidney disease
Dr Neeraj DhaunEmily GoddenOpen to Recruitment

Trauma, Surgical and Orthopaedics

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
PROM OCTSThe creation and field testing of a new rib fracture specific patient reported outcome measure AOUK&I/NIHR HTA ORiFDr Matt ReedNicky FreemanCompleting Follow Up

Paediatrics

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus

Other

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus

Innovation Studies

Biomarker

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
EMBOL1 StudyA Performance Evaluation of The LumiraDX Point of Care D-DIMER Assay LumiraDXProfessor Alasdair GrayJulia GrahamslawIn Set Up
NOVEL StudyCollection of Venous and Capillary Blood Samples for the Development of New Diagnostic Devices for Cardiovascular ConditionsLumiraDXProfessor Alasdair GrayNicky FreemanOpen for Recruitment
REACT StudyA Performance Evaluation of The LumiraDX Point of Care CRP Assay LumiraDXProfessor Alasdair GrayIn Set Up

Medical Wearable Device studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ASPIREDASPIREDMulti-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patientsBritish Heart FoundationDr Matt ReedNicky FreemanIn Set Up

Data Projects

Data Science

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
Improving Multi-Morbidity Acute Care Using Data AnalyticsSBRI: Improving Multi-Morbidity Acute Care Using Data AnalyticsHealth Innovation South East Scotland / Innovate UKNaz Lone/Dr Matt ReedDr Matt ReedOngoing
Improving Care through Data Driven InnovationMultimorbidity and Emergency Healthcare Provision: Improving Care through Data Driven InnovationWellcome Trust ISSF3Naz Lone/Dr Matt ReedDr Matt ReedOngoing