Below are details of all current trials at EMERGE. Either click the area you are interested to see relevant studies or scroll through all our work.

If there is a study you’re interested in that isn’t listed here or you’d like to discuss a study with us then please get in touch. If you’re interested in a commercial collaboration and EMERGE evaluating something for you the please visit our Commercial Collaboration page.

Cardiovascular

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ACUTEACUTEA mechanistic study of intravenous thiamine for acute heart failureMedical Research CouncilProfessor Michael Eddleston&Dr Matt ReedCaroline BlackstockOpen to Recruitment
TARGET-CTCA TrialTroponin in Acute chest pain to Risk stratify and Guide EffecTive use of Computed Tomography Coronary Angiography British Heart FoundationProfessor Nick MillsRachel O’BrienOpen to Recruitment
DAShEDDAShEDThe DAShED (Diagnosis of Acute Aortic Syndrome in the ED) studyRCEMDr Rachel McLatchieRachel O’BrienOpening to Recruitment in September 2022

Stroke and Neurosurgery

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
Can-SCAHnCan-SCAHnSelective neuroimaging for head-injured emergency patients who take anticoagulant medication.Canadian Institutes of Health ResearchDr Matt ReedJulia GrahamslawIn Set Up
ATTEST2 TrialAlteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis Stroke Association & British Heart FoundationDr William WhitelyJessica TeasdaleOpen to Recruitment
AXIOMATIC-SSPAXIOMATIC-SSPAntithrombotic treatment with factor XIa inhibition to Optimize Management of Acute
Thromboembolic events in Secondary Stroke Prevention
Bristol-Myers SquibbDr Neil HunterMichelle CoakleyOpen to Recruitment
BRAIN MATRIXA BRitish feasibility study of molecular stratification and targeted therapy to optimize the clinical mAnagement of patieNts with glioMA by enhancing clinical ouTcomes, Reducing avoidable toXicity, improving management of post-operative residual & recurrent disease and improving survivorshipThe Brain Tumour Charity and Genomics EnglandDr Paul BrennanAllan MacRaildOpen to Recruitment
BRAINED- TBIBRAINED – TBIUsing Fourier Transform Infrared Spectrotroscopy for Earlier Diagnosis and Rapid Stratification of Patients with a Traumatic Brain InjuryNIHR Brain Injury MedTech Co-operative Seedcorn Funding CompetitionDr Paul BrennanPolly BlackCompleting Follow Up
DASH TrialDASH is a randomised clinical trial investigating a treatment to reverse the effects of blood-thinning medications.NIHRProfessor Rustam Al-Shahi SalmanMichelle CoakleyCompleting Follow Up
DENSDuration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collarNIHR HTADr Paul Brennan/Dr Matt ReedPolly BlackOpen to Recruitment
ENRICH-AFENRICH-AFEdoxabaN foR IntraCranial Hemorrhage survivors with Atrial FibrillationDaiichi Sankyo
Company
Professor Rustam Al-Shahi SalmanMichelle CoakleyOpen to Recruitment
HeadOn StudyDelivery of digital cognitive behaviour therpy following concusion: HeadOn Feasibility StudyNIHR Brain Injury, MedTech Co-operative, Seedcorn Funding CompetitionAimun Jamjoom/Dr Matt ReedAlison GrantCompleting Follow Up
INFERENCEIdentificatioN oF biomarkErs foR Early diagNosis of CancErInnovate UKDr Paul BrennanPolly BlackOpen to Recruitment
LINCH-PINLothian study of INtraCerebral Haemorrhage Pathology,
Imaging & Neurological outcome
UK Medical Research
Council and The Stroke Association
Dr Neshika SamarasekeraAllan MacRaildOpen to Recruitment
OPTIMASOPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trialBritish Heart FoundationDr Fergus DougalJessica TeasdaleOpen to Recruitment
PRECIOUSA clinical trial to look at PREvention of Complications to
Improve OUtcome in elderly patients with acute Stroke
European Union’s Horizon 2020 Research and Innovation
Programme
Professor Malcolm MacLeodJessica TeasdaleOpen to Recruitment
R4VADRates, Risks and Routes to Reduce Vascular DementiaStroke Association, Alzheimer’s Society, and British Heart
Foundation
Professor Joanna WardlawRachel SutherlandOpen to Recruitment
Shared Stroke DecisionsShared Stroke DecisionsDevelopment and implementation of Realistic Medicine for severe stroke through Shared Decision MakingEdinburgh and Lothian Health FoundationProfessor Gillian MeadPolly BlackIn Set Up

Toxicology

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
IONAIONAIdentification Of Novel psychoActive substances NIHR portfolioProfessor Michael EddlestonCaroline BlackstockOpen to Recruitment
MAPP2 StudyThe Markers and Paracetamol Poisoning Study 2Rosetrees Trust and Kidney Research UKProfessor James DearEmily GoddenOpen to Recruitment
POP2POP2A Randomised, Double-blind, Placebo-Controlled, Phase 2/3 Study with 2 Doses of Calmangafodipir in Increased Risk Patients Treated with N Acetylcysteine for Acetaminophen/Paracetamol OverdoseEgetis Therapeutics Professor James DearJulia Grahamslaw/Caroline BlackstockIn Set Up

Blood Project Group

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
National Code Red AuditThe aim of this audit is to monitor and optimise the transfusion support given to patients following major trauma in Scotland.SNBTSDr Matt ReedDr Matt ReedOpen

COVID-19

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ISARIC4CClinical Characterisation Protocol for Severe Emerging
Infections in the UK
MRC, Wellcome Trust,
SPRINT-SARI NIHR Health Protection Research Unit (HPRU) in Respiratory Infection, HPRU
in Emerging and Zoonotic Infections
Dr Kenneth BaillieCaroline BlackstockCompleting Follow Up

Sepsis

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ABC SEPSISFeasibility of 5% Albumin compared with Balanced Crystalloid, as intravenous
fluid resuscitation in adult patients with sepsis, presenting as an emergency to
hospital
The Jon Moulton Charity Trust
Professor Alasdair GrayJulia GrahamslawOpen to recruitment
MIS-ABC SepsisMechanistic Inflammatory Sub-study. The Royal College of Emergency Medicine.Dr. Jack CafferkeyJulia GrahamslawOpen to recruitment

Renal

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
AFiRMAFiRMApplication of Functional Renal MRI to improve assessment of chronic kidney diseaseNational Institute for Health ResearchDr Neeraj DhaunEmily GoddenOpen to Recruitment
KRAKIL StudyKidney Recovery after Acute Kidney Injury – Longitudinal studyMedical Research CouncilProfessor James DearEmily GoddenOpen to Recruitment
OCTOCTAssessment of retinal vasculature using optical coherence tomography in
health, hypertension & kidney disease
Dr Neeraj DhaunEmily GoddenOpen to Recruitment

Trauma, Surgical and Orthopaedics

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
RELIEFThe Randomised Evaluation of early topical Lidocaine patches In Elderly patients admitted to hospital with rib Fractures (RELIEF): feasibility trialNorth Bristol NHS TrustDr. Edward CarltonFiona McCurrachOpen to Recruitment

Paediatrics

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
INFORMCare deice for the detection of Influenza A/B, Respiratory Syncytial Virus (RSV) & SARS-COV-2 VirusLumiraDXDr. Jen BrowningIn Set Up

Other

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
CoSTEDCessation Of Smoking Trial in the Emergency DepartmentNorfolk and Norwich University Hospitals NHS
Foundation Trust (NNUH)
Professor Alasdair GrayAnna MiellOpen to Recruitment

Innovation Studies

Biomarker

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
EMBOL1 StudyA Performance Evaluation of The LumiraDX Point of Care D-DIMER Assay LumiraDXProfessor Alasdair GrayCaroline BlackstockOpen for Recruitment
NOVEL StudyCollection of Venous and Capillary Blood Samples for the Development of New Diagnostic Devices for Cardiovascular ConditionsLumiraDXProfessor Alasdair GrayAnna MiellOpen for Recruitment
REACT StudyA Performance Evaluation of The LumiraDX Point of Care CRP Assay LumiraDXProfessor Alasdair GrayCaroline BlackstockOpen for Recruitment

Medical Wearable Device studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ASPIREDMulti-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patientsBritish Heart FoundationDr Matt ReedNicky FreemanOpening to Recruitment in May 2022

Data Projects

Data Science

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
Improving Multi-Morbidity Acute Care Using Data AnalyticsSBRI: Improving Multi-Morbidity Acute Care Using Data AnalyticsHealth Innovation South East Scotland / Innovate UKNaz Lone/Dr Matt ReedDr Matt ReedOngoing
Improving Care through Data Driven InnovationMultimorbidity and Emergency Healthcare Provision: Improving Care through Data Driven InnovationWellcome Trust ISSF3Naz Lone/Dr Matt ReedDr Matt ReedOngoing