Below are details of all current trials at EMERGE. Either click the area you are interested to see relevant studies or scroll through all our work.

If there is a study you’re interested in that isn’t listed here or you’d like to discuss a study with us then please get in touch. If you’re interested in a commercial collaboration and EMERGE evaluating something for you the please visit our Commercial Collaboration page.

Previous Cardiovascular Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
3CPO3CPO TrialA randomised controlled trial of continuous positive airway pressure (CPAP) vs non invasive ventilation (NIV) vs standard therapy for acute pulmonary odema (ACPO)NIHR HTAProfessor Alasdair GrayMoyra MassonClosed to Recruitment
Garfield-VTE StudyGlobal Anticoagulant Registry in the FIELD observing treatment and outcomes in patients with treated acute Venous Thromboembolic Events in the real worldBayer AGDr. Ann LockmanCaroline BlackstockClosed to Recruitment
HighSTEACSHighSTEACS is a randomised controlled trial, across 10 hospitals in NHS Lothian and NHS Greater Glasgow & Clyde, assessing patient outcomes before and after the implementation of high sensitivity Troponin assayBHFProfessor Alasdair GrayRachel O’BrienClosed to Recruitment
HighSTEACS BioresourceHighSTEACS BioresourceEvaluating the kinetics of cardiac biomarkers after ST-segment Elevation myocardial infarctionBHFProfessor Alasdair GrayRachel O’BrienClosed to Recruitment
IPED TrialRandomised controlled Trial using smart phone based event recorder technology versus standard care in palpatations or pre-syncopeCHSS / BHFDr Matt ReedMia PaderangaClosed to Recruitment
PRECISE-CTCAPRECISE-CTCA TrialtroPonin within the noRmal refEerenCe range to risk Stratify patients with acute chEst pain for Computed Tomography Coronary AngiographyBritish Heart FoundationDr Ken LeeRachel O’BrienClosed to Recruitment
PREFERPrefer in VTE Prevention of Thromboembolic Events – European Registry in Venous ThromboembolismEUSEMDr Matt ReedRachel O’Brien & Julia GrahamslawClosed to Recruitment
RAPID-CTCA TrialEvaluate role of early CT Coronary Angiography in the evaluation, intervention and outcome of patients presenting to the Emergency Department with suspected or confirmed Acute Coronary SyndromeBHFProfessor Alasdair GrayRachel O’BrienClosed to Recruitment
RATPACRandomised Assessment of Treatment using Panel Assay of Cardiac markersNIHR HTAProfessor Alasdair GrayJudy CoyleClosed to Recruitment
Relax 2 TrialA multicenter, randomised, double-blind, placebo-controlled phase IIIb study to evaluate the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients (CRLXA).NovartisProfessor Alasdair GrayJulia GrahamslawClosed to Recruitment
ROSEROSERisk Stratification Of Syncope in the Emergency departmentCSODr Matt ReedDr Matt ReedClosed to Recruitment

Previous Stroke and Neurosurgery Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
AHEADAHEADMonitoring anticoagulated patients who suffer head injuryNIHR Research for Patient Benefit Programme Dr Matt ReedJan GilchristClosed to Recruitment
BRAINED StudyBRAINED StudyBlood samples will be assessed using infrared spectroscopy as part of a project looking at tumour biomarkers to ascertain whether people most at risk of having a brain tumour can be correctly identifiedDr Paul BrennanPolly BlackClosed to Recruitment
ETNAETNAEdinburgh Transient and Neurological attack: A Cohort StudyChief Scientist’s OfficeDr Will WhiteleyAllan MacRaildClosed to Recruitment
MRI in Acute StrokeMRI in Acute StrokeMRI in Acute Stroke TimingSpringboard Grant from North Bristol Trust and Dunhill Medical TrustAllan MacRaildClosed to Recruitment
PitSTOP To determine the prevalence of anterior pituitary gland dysfunction in traumatic brain injury in ScotlandDr John EmelifeonwuJulia GrahamslawClosed to Recruitment
TREAT-SVDEffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular
FuncTion in Small Vessel Diseases
European UnionDr Joanna WardlawDr Joanna WardlawClosed to Recruitment
TICH-2 TrialTICH 2 TrialTranexamic Acid for Hyperacute Primary IntraCerebral HaemorrhageNIHRProfessor Rustam Al-Shahi SalmanAllan MacRaildClosed to Recruitment

Previous Toxicology Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
MUPMinimal Unit Pricing Study (MUP)Measure the effect of Minimum Unit Pricing in Emergency Care SettingsNIHRDr Michelle OpenEmma MoattClosed to Recruitment
The POP TrialProfessor James DearAllan MacRaildClosed to Recruitment
SNAP TrialScottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning StudyProfessor James DearJudy CoyleClosed to Recruitment

Previous Blood Project Group Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
DEUCEIs Rotational Thromboelastometry (ROTEM) useful to detect Occult Coagulopathy in the Emergency Department?SNBTSDr Matt ReedAllan MacRaildClosed to Recruitment
E-FIT1E-FIT1 TrialRCT or fibrinogen concentrate within 45 minutes of admission to hospital in adult trauma patients with severe bleedingCSL BehringDr Matt ReedBernadette GallagherClosed to Recruitment
Halt-It TrialTranexamic acid for the treatment of gastrointestinal haemorrhage: an international randomised, double blind placebo controlled trialNIHR HTADr Matt ReedJulia GrahamslawClosed to Recruitment
National Code Red AuditThe aim of this audit is to monitor and optimise the transfusion support given to patients following major trauma in Scotland.SNBTSDr Matt ReedDr Matt ReedClosed to Recruitment
NoPac TrialTranexamic acid for the treatment of epistaxis: a randomised, double blind placebo controlled trialNIHR RfPBDr Matt ReedPolly BlackClosed to Recruitment
TRIGGERTRIGGERTransfusion in Gastrointestinal BleedingNHS Blood and Transplant Research and Development.Professor Alasdair GrayRachel O’BrienClosed to Recruitment

Previous COVID-19 Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
CERAUnderstand the evolving and cumulative effects of working during the COVID-19 outbreak on the psychological health of those physicians working in the emergency care settings across the UKEmily Godden&Emma MoattClosed to Recruitment
PRIESTEvaluate current triage methods used to determine if a patient with suspected COVID-19 is to be admitted to hospital or not and whether or not they should be admitted to ICU/HDUPolly BlackClosed to Recruitment
BreathSpec-COVIDBreath analysis for the detection of COVID19RCEMDr Matt ReedRachel O’BrienClosed to Recruitment
PAN-EDPAN-EDEmily Godden&Emma MoattEmily Godden&Emma MoattClosed to Recruitment
COV_002 Vaccine TrialCOV_002 Vaccine TrialTo test a new vaccine, ChAdOx1 nCoV-19, against COVID-19 in healthy volunteersRachel O’BrienClosed to Recruitment

Previous Trauma, Surgical and Orthopaedics Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
HU-FIX TrialA trial of operative versus conservative management in humeral shaft fracturesClosed to Recruitment

Previous Sepsis Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
LAVAS StudyLactate, Arterial and Venous Agreement in SepsisDr Dip DattaJulia GrahamslawClosed to Recruitment
ExPRES SEPSISTo derive a biomarker to allow the identification of patients with confirmed sepsis, and risk stratify patients at risk of developing severe sepsisProfessor Tim WalshJulia GrahamslawClosed to Recruitment
CVLA StudyCapillary and Venous Lactate Agreement – a pilot observational studyDr Dip DattaJulia GrahamslawClosed to Recruitment

Previous Paediatric Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
EcLiPSEEcLiPSE TrialComparing intravenous levetiracetam to intravenous phenytoin for the treatment of convulsive status epilepticus (CSE) in children, young people and young adultsNIHR HTADr Jen BrowningJulia GrahamslawClosed to Recruitment

Other Previous Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
Time and MotionTo explore the time taken for research nurses to recruit patients in an Emergency Department (ED) settingn/aRachel O’Brien& Polly BlackRachel O’Brien& Polly BlackClosed to Recruitment
EURODEMThe European Dyspnoea survey in the Emergency DepartmentsEUSEMDr Matt ReedRachel O’BrienClosed to Recruitment
POEMAssess the adequacy of pain management in patients presenting to the ED with confirmed long bone fracture and/or dislocation isolated to a proximal or distal limbClosed to Recruitment
First 'First Responder'First “First Responder” StudyProvide the first in-depth look into the experience of the OHCA bystander responderJoel SymondsClosed to Recruitment
ENCEPH UK StudyENCEPH UK StudyTo produce a predictive tool for HSV encephalitis based on the early clinical features, by comparing the clinical features of those with and without HSV encephalitisNIHR Programme for Applied ResearchDr Matt ReedJulia GrahamslawClosed to Recruitment
4AT StudyTo determine the diagnostic accuracy of the 4AT for delirium versus the reference standard of a DSM-IV diagnosisClosed to Recruitment
3MG TrialA randomised trial of intravenous or nebulised magnesium sulphate versus placebo for acute severe asthmaNIHR HTAProfessor Alasdair GrayMoyra MassonClosed to Recruitment
COPSDr Frank PriorDr Frank PriorClosed to Recruitment
The Prior StudyPlot the Membrane Osmotic Pressure (MOP) and Mean arterial pressure (MAP) of healthy participants onto a chart that has been created from previous workDr Frank PriorDr Frank PriorClosed to Recruitment

Innovation Studies

Previous Biomarker Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
AKI in LC StudyA study of AKI in hospital patientsFiona GiffordCaroline BlackstockClosed to Recruitment
EHA StudyA diagnostic screening study for hereditary angioedema in the EDCentrogeneDr Matt ReedFiona McCurrachClosed to Recruitment
TPTIHTPTIHTo establish genetic associations between patients with thiazide-induced hyponatraemia and patients taking a thiazide who did not develop hyponatraemiaAnn LockmanCaroline BlackstockClosed to Recruitment

Previous Medical Wearable Device Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
PATCH-EDDiagnostic yield of an ambulatory patch monitor in Emergency Department syncope patients unexplained after Emergency Department evaluationChest, Heart and Stroke ScotlandDr Matt ReedKirsty SimpsonClosed to Recruitment
RAMPP trialInvestigate the use of a pleural vent (rocket) versus standard care in patients with Primary Spontaneous Pnuemothorax in a randomised controlled trialMedical Research Council and the National Institute for Health Research (UK)Dr Marie-Clare HarrisMia PaderangaClosed to Recruitment

Data Projects

Previous Data Science Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus