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Active Projects

ATTEST2 Trial

Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST 2)

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ATTEST2 Trial

Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST 2)

SABER Study

Developing a molecular tool to stratify the acute joint presentation: facilitating early diagnosis of septic arthritis (Septic Arthritis Biomarker Emergency Rule-out - SABER)

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SABER Study

Developing a molecular tool to stratify the acute joint presentation: facilitating early diagnosis of septic arthritis (Septic Arthritis Biomarker Emergency Rule-out - SABER)

BRAINED Study

Molecular and cellular analysis of intracranial tumours

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BRAINED Study

Molecular and cellular analysis of intracranial tumours

MAPP2 Study

The Markers and Paracetamol Poisoning Study 2

NOVEL Study

Diagnostics devices play an important part in the clinical assessment of a patient’s health and treatment. The purpose of the study is the evaluation of a new diagnostic platform developed by LumiraDx. The evaluation is focused around various biomarkers useful in the emergency settings.

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NOVEL Study

Collection of venous and capillary blood samples for the evaluation of new diagnostic devices for cardiovascular conditions

HU-FIX Trial

Assisting in identifying patients with Humeral shaft fractures in the ED by screening.

Giving patient information sheets to introduce the study, so patient has had adequate time to read and make decision about going into the trial before going to the fracture clinic.

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HU-FIX Trial

EHA Study

EHA - Epidemiological analysis for the Hereditary Angioedema Disease is an international, multicentre, epidemiological study that aims to explore the feasibility of a new Dried Blood Spot (DBS) filtercard-based screening algorithm and thereby the prevalence of the Hereditary Angioedema.

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EHA Study

EHA - Epidemiological analysis for the Hereditary Angioedema Disease

DASH Trial

DASH is a randomised clinical trial investigating a treatment to reverse the effects of blood-thinning medications.

TARGET-CTCA Trial

TARGET CTCA is a joint venture between EMERGE and the cardiology research team aiming to recruit patients with suspected ACS across NHS Lothian and NHS Greater Glasgow and Clyde. The study aims to recruit 2270 participants. For further information, please contact the EMERGE team.

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TARGET-CTCA Trial

HEAD Study

Prospective multicentre observational study conducted over one calendar month in 2019, with the aim of describing the epidemiology of non-trauma related headache in adults presenting to emergency departments including investigations, treatments and outcome.

This will include adult patients presenting to the ED with non-trauma-related headache as their primary complaint.

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HEAD Study

RAPID-CTCA Trial

Evaluating the role of early CT Coronary Angiography on patients with suspected or confirmed Acute Coronary Syndrome.

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RAPID-CTCA Trial

Evaluating the role of early CT Coronary Angiography

SALI Study

This is a study looking at incidence and risk factors for poor ankle functional recovery, and the development and progression of post-traumatic ankle osteoarthritis after significant ankle ligament injury.

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SALI Study

SALI study - Significant Ankle Ligament Injury

Research on Research

Attitudes towards Research and Research Nurses among the clinical team in an Emergency Department (ED) and Acute Medical Unit (AMU)

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Research on Research

Attitudes towards Research and Research Nurses

IONA Study

Identification and characterization of the clinical toxicology of novel psychoactive substances (NPS) by laboratory analysis of biological samples from recreational drug users.

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IONA Study

Identification of Novel Psychoactive Substances (IONA)

EMERGE Biobank

The Emergency Medicine Annotated Bioresource Consortium (EM-ABC): A pilot and feasability programme

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EMERGE Biobank

Developing a bioresource for all emergency presentations

Garfield-VTE Study

Global Anticoagulant Registry in the FIELD observing treatment and outcomes in patients with treated acute Venous Thromboembolic Events in the real world

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Garfield-VTE Study

Global Anticoagulant Registry In the FIELD – Venous Thromboembolic Events


Projects Coming Soon

EMBOL1 Study

A Performance Evaluation of The Lumiradx Point of Care D Dimer Assay AS AN Aid in the Diagnosis and Assessment of VTE (EMBOL1)

REACT Study

A performance evaluation study designed to assess the precision and accuracy of the Lumira DX point of care (POC) and C-Reactive (CRP) assay as an aid in the detection and evaluation of infection, tissue injury and inflammatory disorders.

In the emergency department (ED), CRP is tested in patients presenting with a variety of symptoms as an aid the detection and evaluation of infection, tissue injury or inflammatory disorders.

Primary objective - To determine the performance of the LumiraDx POC CRP assay when compared to the Siemens Dimension reference method in patients with symptoms of infection, tissue injury and inflammatory disorders.

Sample size - 50 participants over a duration of approximately 4 weeks.

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REACT Study

KRAKIL Study

People who develop an Acute Kidney Injury (AKI) often have a poor prognosis and many go on to develop chronic kidney disease (CKD). The recognition that AKI and CKD are linked is recent and the molecular pathways that control the transition from acute injury to chronic disease are not well defined. Currently there are no specific treatments that reduce the risk of progressing to CKD after AKI.

Preliminary investigations (not yet published) suggest that AKI causes sustained activation of the endothelin (ET) system to the long-term detriment of renal and systemic haemodynamic function. These pilot data form the basis of our project that seeks to determine whether the ET system is active in patients with AKI and, thus, represents a potential target for therapeutic intervention.

KRAKIL aims to recruit altogether 100 patients from across the emergency department, acute medical unit and inpatient wards at the Royal Infirmary. 50 of which with AKI’s and 50 matched controls with normal kidney function. We will monitor their bloods and urine for 90 days and compare the data from between the two groups.

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KRAKIL Study

Closed Projects

TRIGGER

Evaluating the feasibility and safety of implementing a restrictive versus liberal red blood cell (RBC) transfusion policy.

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TRIGGER

Transfusion in Gastrointestinal Bleeding

Time and Motion

To explore the time taken for research nurses to recruit patients in an Emergency Department (ED) setting.

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Time and Motion

Time and Motion

SNAP Trial

Assesing the effectiveness ondansetron at reducing nausea and vomiting in patients treated with regimen for paracetamol poisoning

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SNAP Trial

Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study

ROSE

Developing a Clinical Decision Rule for patients presenting with syncope to the Emergency Department

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ROSE

Risk Stratification Of Syncope in the Emergency department

Relax 2 Trial

Evaluating the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients (CRLXA).

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Relax 2 Trial

Evaluating Serelaxin in acute heart failure patients

RATPAC

Randomised Assessment of Treatment using Panel Assay of Cardiac markers - a trial of rapid blood testing for acute chest pain in six NHS hospitals around the UK.

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RATPAC

Assesing rapid blood testing for acute chest pain

SNAP40 Study

Detection of physiological deterioration by the SNAP40 wearable device compared to standard monitoring devices in the Emergency Department

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SNAP40 Study

Evaluating the role of ambulatory, wireless vital sign monitoring in the detection of deterioration

PREFER

Assessing the direct health care resource use and costs following acute first-time or recurrent VTE

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PREFER

Prefer in VTE Prevention of Thromboembolic Events

LAVAS Study

Determining whether an agreement between peripheral venous and arterial lactate exists in patients presenting to an Emergency Department with sepsis.

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LAVAS Study

Lactate, Arterial and Venous Agreement in Sepsis

HighSTEACS

A randomised controlled trial assessing patient outcomes before and after the implementation of high sensitivity Troponin assay

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HighSTEACS

Assessing the implementation of high sensitivity Troponin assay

PATCH-ED

Diagnostic yield of an ambulatory patch monitor in Emergency Department syncope patients.

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PATCH-ED

Diagnostic yield of an ambulatory patch monitor in ED

Halt-It Trial

Tranexamic acid for the treatment of gastrointestinal haemorrhage: an international randomised, double blind placebo controlled trial

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Halt-It Trial

Tranexamic acid for the treatment of gastrointestinal haemorrhage

Code Red

Auditting, monitoring and optimising the transfusion support given to trauma patients in Scotland

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Code Red

Transfusion and Laboratory support in Trauma Group Code Red Audit

ExPRES SEPSIS

To derive a biomarker to allow the identification of patients with confirmed sepsis, and risk stratify patients at risk of developing severe sepsis

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ExPRES SEPSIS

Early Prediction of Severe Sepsis

TICH 2 Trial

Assessing tranexamic acid after hyperacute spontaneous intracerebral haemorrhage.

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TICH 2 Trial

Tranexamic Acid for Hyperacute Primary IntraCerebral Haemorrhage

Blood Project

To co-ordinate and support RIE ED Emergency Transfusion research and audit and disseminate our findings

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Blood Project

The Edinburgh ED Blood Project

EURODEM

Epidemiologic description of patients presenting to the ED with shortness of breath.

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EURODEM

The European Dyspnoea survey in the Emergency departments

First “First Responder” Study

While considerable efforts have been made to determine the best ways to perform cardiopulmonary resuscitation (CPR) for persons suffering an out-of-hospital cardiac arrest (OHCA), and also to understand what the physical and psychological impact on the victim might be, very little is known about what actually occurs when a lay bystander is suddenly confronted by someone in cardiac arrest.

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First “First Responder” Study

The First “First Responder”: Understanding bystander actions, experience, and well-being in out-of-hospital cardiac arrest

TPTIH

The Pharmacogenetics of Thiazide Induced Hyponatraemia

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TPTIH

The Pharmacogenetics of Thiazide Induced Hyponatraemia

POEM

An investigation into the Prescription of Analgesia in Emergency Medicine (POEM).

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POEM

Prescription of Analgesia in Emergency Medicine (POEM)

DEUCE

Is Rotational Thromboelastometry (ROTEM) useful to detect Occult Coagulopathy in the Emergency Department?

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DEUCE

Evaluating Rotational Thromboelastometry (ROTEM) in detecting Occult Coagulopathy

MRI in Acute Stroke

Strokes caused by a clot are described as ischaemic. When patients experience ischaemic strokes they may be eligible for “clot busting” therapy (thrombolysis). Currently thrombolysis has been shown to improve patient outcome after a stroke if administered within the first 4.5 hours after stroke onset. Up to 25% of patients wake up with symptoms of a stroke. This means they have an unknown onset time for their stroke (so called ‘wake up strokes’). With no known onset time, they are ineligible for thrombolysis. This study will investigate how we might determine stroke onset time.

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MRI in Acute Stroke

HighSTEACS Bioresource

Evaluating the kinetics of cardiac biomarkers after ST-segment Elevation myocardial infarction

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HighSTEACS Bioresource

CVLA Study

Determining the feasibility of a study investigating the agreement between capillary and peripheral venous lactate in the Emergency Department

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CVLA Study

Capillary and Venous Lactate Agreement

EcLiPSE Trial

This trial is a two arm, multicentre parallel group, randomised controlled, open label trial comparing intravenous levetiracetam to intravenous phenytoin for the treatment of convulsive status epilepticus (CSE) in children, young people and young adults.

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EcLiPSE Trial

Emergency Treatment with Levetiracetam or Phenytoin in Status Epilepticus in Children (EcLiPSE) – an open label randomised controlled trial

RAMPP trial

Intervention
1. Ambulatory Device, Rocket Pleural vent insertion
2. Standard Treatment, Aspiration +/- chest drain
Primary Outcome Measures
To assess whether use of an ambulatory device (Rocket Pleural Vent) and treatment strategy reduces hospital stay. Total length of stay in hospital up to 30 days post randomisation. Up to 30 days post randomisation.

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RAMPP trial

RAMPP trial - Randomised Controlled Trial: Pleural vent (rocket) V standard care in Primary Spontaneous Pnuemothorax

AHEAD

Identifying the outcomes of anticoagulated patients attending the ED following head injury

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AHEAD

Monitoring anticoagulated patients who suffer head injury

NoPac Trial

Patients commonly present to the Emergency Department with epistaxsis (nose bleed). Standard first aid measures such as applying pressure can often stem bleeding however in more severe cases of epistaxsis further treatment is required.

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NoPac Trial

Novel Use of Tranexamic Acid to Reduce the Need for Nasal Packing

3CPO Trial

Continuous positive airway pressure vs non invasive ventilation vs standard therapy for acute pulmonary odema

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3CPO Trial

AKI in LC Study

In the Liver Unit at the Royal Infirmary of Edinburgh, we are involved in research to improve the treatment available for people with liver cirrhosis. Cirrhosis of the liver can make people vulnerable to other potentially serious complications including kidney problems.

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AKI in LC Study

ENCEPH UK Study

To produce a predictive tool for HSV encephalitis by comparing those with and without the infection.

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ENCEPH UK Study

Understanding and improving the outcome in Encephalitis

4AT Study

Determining the diagnostic accuracy of the 4AT for delirium versus the reference standard of a DSM-IV diagnosis

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4AT Study

The 4AT as a triage test for delirium: a validation study in acutely hospitalised older patients

3MG Trial

Assessing the effectiveness of IV and nebulised magnesium sulphate in the treatment of acute severe asthma.

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3MG Trial

Intravenous or nebulised magnesium sulphate versus placebo for acute severe asthma.

IPED Trial

Randomised controlled Trial using smart phone based event recorder technology versus standard care in palpatations or pre-syncope

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IPED Trial

Randomised controlled Trial using smart phone based event recorder technology versus standard care in palpatations or pre-syncope

COPS

This study contributes to the work of Dr Frank Prior who is developing a tool to be used in the treatment of shock.
It is known that shock creates a set of internal conditions that affect vasculature and that these conditions can vary over time and are dependent on the type of shock. This tool reveals the condition of the vasculature and therefore informs which fluid and drugs are best advised for that patient at that time.

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COPS

Calculating Osmotic Pressure in Healthy Patients (COPs)

The POP Trial

The study with PP100-01 in combination with NAC is designed to determine safety and tolerability of PP100-01 when co-administered with NAC as compared to the 12-hr NAC treatment regime for patients that come to the hospital after an overdose of paracetamol/acetaminophen.

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The POP Trial

A Randomised Open Label Exploratory, Safety and Tolerability Study with PP100-01 in Patients Treated with the 12-hour Regimen of N-Acetylcysteine for Paracetamol/Acetaminophen Overdose

E-FIT1 Trial

A multi-centre, randomised, double blind, placebo-controlled trial evaluating the effects of early administration of fibrinogen concentrate in adults with major traumatic haemorrhage. E-FIT1 Study

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E-FIT1 Trial

A multi-centre, randomised, double blind, placebo-controlled trial evaluating the effects of early administration of fibrinogen concentrate in adults with major traumatic haemorrhage. E-FIT 1 Study

SECUre – A Multicentre Survey of the Safety of Emergency Care in UK Emergency Departments

To provide an overview of safety culture and patient safety issues in UK emergency departments, and to determine if there are significant differences between doctors and nurses’ perception of safety issues.

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SECUre – A Multicentre Survey of the Safety of Emergency Care in UK Emergency Departments

SECUre – A Multicentre Survey of the Safety of Emergency Care in UK Emergency Departments

The Prior Study

This study will investigate how we can help treat patients suffering from shock by the targeted use of specific fluids and medications. Shock is an acute medical condition in which the organs and tissues of the body are not receiving an adequate flow of blood. It is associated with a fall in blood pressure, a build-up in waste products and can result in serious organ damage and even death. We hope to improve our ability to treat shock by evaluating fluid management from the blood samples of a group of healthy volunteers.

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The Prior Study

Calculating Osmotic Pressure in Healthy Patients

PitSTOP

Traumatic Brain Injury (TBI) is the leading cause of death and disabilities amongst young people worldwide. Many sufferers develop chronic physical and mental health problems and are unable to work or re-engage socially after their injuries. There are therefore significant health and socioeconomic consequences.

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PitSTOP

A study examining the Prevalence and Risk of Anterior Pituitary Dysfunction following Traumatic Brain Injury

Minimal Unit Pricing Study (MUP)

Assessing the impact of the Minimum Unit Pricing

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Minimal Unit Pricing Study (MUP)

Assessing the impact of the Minimum Unit Pricing

PRECISE-CTCA Trial

To determine the association between high-sensitivity cardiac troponin concentration and obstructive coronary artery disease in patients presenting to the Emergency Department with suspected acute coronary syndrome and cardiac troponin concentration within the normal reference range using CTCA.

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PRECISE-CTCA Trial

To determine the association between high-sensitivity cardiac troponin concentration and obstructive coronary artery disease in patients presenting to the Emergency Department with suspected acute coronary syndrome and cardiac troponin concentration within the normal reference range using CTCA.