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EcLiPSE

Start date:
February 2015
End date:
March 2018
Co-ordinated by:
Dr Richard Appleton, The University of Liverpool, Alder Hay Children's Hospital
Main trial site:
RIE

This trial is a two arm, multicentre parallel group, randomised controlled, open label trial comparing intravenous levetiracetam to intravenous phenytoin for the treatment of convulsive status epilepticus (CSE) in children, young people and young adults.

The trial will run in emergency depatments in NHS secondary and tertiary hospitals in the UK, a total of 308 participants will be recruited and total study duration for each participant will be 24 hours. The Consent study will run alongside EcLiPSE and will involve parents who have been approached about the study and EcLiPSE recruiters. The study will examine approaches to recruitment and deferred consent and explore the views of parents with the aim of identifying recruitment and consent issues and potential solutions to inform EcLiPSE recruiter training materials.

Local PI

Dr Jen Browning

Consultant Paediatrican in Emergency Medicine

Research Team

Julia Grahamslaw

Lead Research Nurse

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This trial is a two arm, multicentre parallel group, randomised controlled, open label trial comparing intravenous levetiracetam to intravenous phenytoin for the treatment of convulsive status epilepticus (CSE) in children, young people and young adults.

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Emergency Treatment with Levetiracetam or Phenytoin in Status Epilepticus in Children (EcLiPSE) – an open label randomised controlled trial