Below are details of all current trials at EMERGE. Either click the area you are interested to see relevant studies or scroll through all our work.

If there is a study you’re interested in that isn’t listed here or you’d like to discuss a study with us then please get in touch. If you’re interested in a commercial collaboration and EMERGE evaluating something for you the please visit our Commercial Collaboration page.

Cardiovascular

Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status

ASPIRED	Multi-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients	British Heart Foundation	Professor Matt Reed	Caroline Blackstock	Open to Recruitment
POC-ET	Point of Care Evaluation of high-sensitivity cardiac Troponin (POC-ET) study	British Heart Foundation	Professor Nick Mills	Fiona McCurrach	Open to Recruitment
TARGET-CTCA Trial	Troponin in Acute chest pain to Risk stratify and Guide EffecTive use of Computed Tomography Coronary Angiography	British Heart Foundation	Professor Nick Mills	Rachel O’Brien	Closed - in analysis stage

Stroke and Neurosurgery

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
BRAINED3	BRAINED3	Assessing the performance of Infrared blood-based spectroscopy technology and its ability to identify patients suffering from non-specific symptoms who have a brain cancer.		Dr Paul Brennan	Shona McDonald	Open for Recruitment
	BRAIN MATRIX	A BRitish feasibility study of molecular stratification and targeted therapy to optimize the clinical mAnagement of patieNts with glioMA by enhancing clinical ouTcomes, Reducing avoidable toXicity, improving management of post-operative residual & recurrent disease and improving survivorship	The Brain Tumour Charity and Genomics England	Dr Paul Brennan	Allan MacRaild	Open to Recruitment
Cerebral Spinal Fluid (CSF) Collection	Cerebral Spinal Fluid (CSF) Collection	Collection of otherwise discarded surplus brain tissue from tumour surgery via the NHS Lothian BioResource	Race Against Dementia/ James Dyson Foundation	Dr Paul Brennan, Claire Durrant	Allan MacRaild	Open to Recruitment
	Feasibility Study of the CT Clock Tool for Estimating Onset Time of Ischaemic Stroke	Feasibility Study of the CT Clock Tool for Estimating Onset Time of Ischaemic Stroke. Our proposed CT Clock Tool method for estimating the time of stroke onset (and thus clarifying individual patient eligibility for effective treatment) is significantly simpler to use in the acute setting than the advanced methods currently available (CT perfusion or MRI)	MRC (Medical Research Council) Impact Acceleration Account (IAA)	Dr Grant Mair	Allan MacRaild	Open to Recruitment
ENRICH-AF	ENRICH-AF	EdoxabaN foR IntraCranial Hemorrhage survivors with Atrial Fibrillation	Daiichi Sankyo Company	Professor Rustam Al-Shahi Salman	Anuka Boldbaatar	Open to Recruitment
	IMPACT	International Post Market Product Surveillance Study of Intracranial Aneurysms Treated with an Endovascular Approach	STRYKER	Dr Jonny Downer	Allan MacRaild	Open to Recruitment
Live Human Brain Tissue Collection	Live Human Brain Tissue Collection	Collection of otherwise discarded surplus brain tissue from tumour surgery via the NHS Lothian BioResource	Race Against Dementia/ James Dyson Foundation	Dr Paul Brennan, Claire Durrant	Allan MacRaild	Open to Recruitment
	MAST	MAST-Prophylaxis and MAST-Duration trials aim to define best practice in the use of anti-epileptic drugs for patients following a traumatic brain injury	NIHR	Dr Paul Brennan	Anuka Boldbaatar	Open to Recruitment
	Oceanic Stroke	Phase 3 study to investigate the efficacy and safety of the oral FXIa inhibitor asundexian (BAY 2433334) compared with placebo in participants after an acute non-cardioembolic ischemic stroke or high-risk TIA	Bayer AG	Neil Hunter	Sarah Risbridger	Open to Recruitment
	PhEAST	Pharyngeal Electrical stimulation for Acute Stroke dysphagia Trial	National Institute of Health Research Health Technology Assessment program Devices supplied by Phagenesis Ltd	Richard O’Brien	Sarah Risbridger	Open to Recruitment
	PLINTH	PLatform study for INTracerebral Haemorrhage (PLINTH): community-based feasibility study	Chief Scientist Office	Professor Rustam Al-Shahi Salman	Allan MacRaild	Open to Recruitment
	PreSize	Real-World Performance Evaluation of PreSize Neurovascular Medical Software in a Clinical Setting	Oxford Heartbeat	Dr Jonny Downer	Sarah Risbridger	Open to Recruitment
	TICH-3	A randomised double-blind trial to assess the clinical effectiveness of Tranexamic acid after ICH and determine whether Tranexamic acid should be used in clinical practice.	NIHR	Neshika Samarasekera	Anuka Boldbaatar	Open to Recruitment
	TREAT	Trenza Embolization Device for Intrasaccular Aneurysm Treatment	STRYKER	Dr Jonny Downer	Allan MacRaild	Open to Recruitment
	TRIDENT	Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial		Neshika Samarasekera	Allan MacRaild	Closed to Recruitment
	SEALANT	SEALANT: Safety and Effectiveness Analysis of stent assisted coiling with LVIS® Evo™ and HydroCoil® Embolic System in ANeurysm Treatment	Microvention	Dr Jonny Downer	Anuka Boldbaatar	Closed to Recruitment
Assessing Treatment and Outcome of Patients With Primary Brain Tumours	Assessing Treatment and Outcome of Patients With Primary Brain Tumours	Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Diagnosed According to cIMPACT-NOW Recommendations and the 2021 WHO Classification	European Organisation for Research and Treatment of Cancer - EORTC	Dr Paul Brennan	Anuka Boldbaatar	In Set Up
EASE	EASE: Evaluating Antidepressants for emotionaliSm after stroke	Evaluating Antidepressants for emotionaliSm after stroke	NIHR	Yvonne Chun	Anuka Boldbaatar	In Set Up
RESTART-tICH	RESTART-tICH	A Randomised Trial of Timing to Restart Direct Oral Anticoagulants after Traumatic Intracranial Haemorrhage	NIHR	Dr Paul Brennan	Anuka Boldbaatar	In Set Up
	STOP ‘EM	Surgeons Trial Of Prophylaxis for Epilepsy in seizure naive patients with Meningioma: a randomised controlled trial	NIHR	Dr Paul Brennan	Anuka Boldbaatar	In Set Up

Toxicology

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	HiSNAP	The HiSNAP Trial aims to test conventional (200mg/kg) versus higher (450mg/kg and 600mg/kg) doses of the drug N-Acetylcysteine (known as NAC) which is commonly used to treat the effects of paracetamol overdose	Chief Scientist Office	Professor James Dear	Anna Miell	Open to Recruitment
TIPSS	TIPSS	This trial aims to determine where in the body sulbutiamine/benfotiamine is converted to thiamine.	Medical Research Council (MRC) (Confidence in Concept Fund)	Professor Michael Eddleston	Anna Miell	Closed
Thiamine in CSF	Thiamine in CSF	This study aims to compare several forms of thiamine by testing the absorption into the blood and cerebrospinal fluid (CSF) at different time points after taking a dose		Professor Michael Eddleston	Anna Miell	Closed
POC-DILI	POC-DILI	The Point-of-care Assessment of Drug-Induced Liver Injury (POC-DILI) Study aims to develop blood testing for liver injury during the early stages of assessment of people who have taken a paracetamol overdose.	Medical Research Council (MRC)	Professor James Dear	Anna Miell	In Set Up
POP2	POP2	A Randomised, Double-blind, Placebo-Controlled, Phase 2/3 Study with 2 Doses of Calmangafodipir in Increased Risk Patients Treated with N Acetylcysteine for Acetaminophen/Paracetamol Overdose	Egetis Therapeutics	Professor James Dear	Julia Grahamslaw/Caroline Blackstock	In Set Up

Blood Project Group

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	National Code Red Audit	The aim of this audit is to monitor and optimise the transfusion support given to patients following major trauma in Scotland.	SNBTS	Professor Matt Reed	Professor Matt Reed	Open to Recruitment

Sepsis

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	EVIS	Early Vasopressors in Sepsis		Dr. Alasdair Corfield	Julia Grahamslaw &Fiona McCurrach	Open to Recruitment

Renal

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
CRAFT-CTCA	CRAFT-CTCA	Observational study in patients with kidney failure who are on the waitlist for a kidney transplant.		Professor 'Bean' Neeraj Dhaun	Beth Morrison	Open to Recruitment
OCT	OCT	Assessment of retinal vasculature using optical coherence tomography in health, hypertension & kidney disease		Professor 'Bean' Neeraj Dhaun	Beth Morrison	Open to Recruitment
SPARVASC	SPARVASC	SPARsentan treatment in VASCulitis - Endothelin receptor antagonism to reduce cardiovascular risk in ANCA-associated vasculitis.	University of Edinburgh & (collaborator) Travere Therapeutics, Inc.	Professor 'Bean' Neeraj Dhaun	Beth Morrison	Open to Recruitment
AFiRM	AFiRM	Application of Functional Renal MRI to improve assessment of chronic kidney disease	National Institute for Health Research	Professor 'Bean' Neeraj Dhaun	Beth Morrison	Closed to Recruitment
	KRAKIL Study	Kidney Recovery after Acute Kidney Injury – Longitudinal study	Medical Research Council	Professor James Dear	Beth Morrison	Closed to Recruitment
Spartan	Spartan	Investigating sparsentan treatment in renin angiotensin system (RAS) blockade-naïve patients with biopsy-proven immunoglobulin A nephropathy (IgAN).		Professor 'Bean' Neeraj Dhaun	Beth Morrison	Closed to Recruitment

Trauma, Surgical and Orthopaedics

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	RELIEF	The Randomised Evaluation of early topical Lidocaine patches In Elderly patients admitted to hospital with rib Fractures (RELIEF): feasibility trial	North Bristol NHS Trust	Dr. Edward Carlton	Fiona McCurrach	Completing Follow Up
RACER	RACER	Robotic Arthroplasty: a Clinical and cost Effectiveness Randomised controlled trial		Ms Chloe Scott	Victoria Minnis	Closed to Recruitment

Paediatrics

Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
BACHb	Breathing Assistance in CHildren with bronchiolitis (BACHb): a group-sequential two-stratum multicentre open-label randomised clinical trial of respiratory support in infants with acute bronchiolitis	National Institute of Health Research	Dr David Armstrong	Caroline Blackstock	Open to recruitment
MAST	Pharmacological Management of Seizures post Traumatic Brain Injury.	NIHR	Dr Jay Shetty	Ashleigh Hegan	Open to recruitment
FIDO	Validating clinical decision aids for the assessment and management of febrile infants presenting to emergency care in the UK and Ireland.	Royal College of Emergency Medicine Doctoral Fellowship	Dr Thomas Waterfield	Ashleigh Hegan	Closed to Recruitment

Other

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	CoMiTED	Conservative Management in Traumatic Pneumothoraces in the Emergency Department (CoMiTED)	NIHR-HTA	Professor Edward Carlton/Dr Lyle Moncur	Caroline Blackstock	Open to Recruitment
	CONSEPT	Conservative versus Standard care for primary spontaneous Pneumothorax (CONSEPT)	North Bristol NHS Trust Research & Innovation	Dr Marie-Clare Harris	Alison Grant	Open to Recruitment
	MAIL	Macrophage Therapy For Acute Liver Injury (MAIL) Trial: A Phase 1 Randomised, Blinded, Dose-Escalation Study to Evaluate Safety, Tolerability, and Activity of Allogeneic Alternatively Activated Macrophages (AAM) in Patients with Paracetamol-induced Acute Liver Injury.		Professor James Dear	Alison Grant	Open to Recruitment
POS-ARI-ER	POS-ARI-ER	The POS-ARI-ER study is a multicentre, Perpetual Observational Study of patients with suspected Acute Respiratory Infections presenting via Emergency Rooms and other acute hospital care settings.		Dr Jon Carter	Shona McDonald	Open to Recruitment
	RECOVERY Trial	RECOVERY is an international clinical trial identifying treatments that be beneficial for people hospitalised with pneumonia	NIHR Oxford Biomedical Research Centre, the Wellcome Trust	Professor Alasdair Gray	Rachel O’Brien	Open to Recruitment
	CoSTED	Cessation Of Smoking Trial in the Emergency Department	Norfolk and Norwich University Hospitals NHS Foundation Trust (NNUH)	Professor Alasdair Gray	Anna Miell	Closed to Recruitment
FORCE:SEE	FORCE:SEE	Frailty and Outcomes Record in Clinical Environments: probable Sarcopenia, geriatric Evaluation, and Events		Dr Alixe Kilgour	Victoria Minnis	Closed to Recruitment

Innovation Studies

Biomarker

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	NOVEL2 Study	Collection of Venous and Capillary Blood Samples for the Development of New Diagnostic Devices for Cardiovascular Conditions	LumiraDX	Professor Alasdair Gray	Ellise Clarke	Open to Recruitment
	PERFORM-TSIX	Clinical Performance of Elecsys® Troponin T hs Gen 6 in Subjects with Symptoms of Acute Coronary Syndrome. The purpose of this research study is to evaluate the performance of the investigational diagnostic test which may help doctors diagnose heart attacks faster and more accurately than they can today.	Roche	Professor Richard Body/ Dr Stephen Lynch	Caroline Blackstock	Closed to Recruitment

Medical Wearable Device studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	ASPIRED	Multi-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients	British Heart Foundation	Professor Matt Reed	Caroline Blackstock	Open to Recruitment

Data Projects

Data Science

Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
Improving Multi-Morbidity Acute Care Using Data Analytics	SBRI: Improving Multi-Morbidity Acute Care Using Data Analytics	Health Innovation South East Scotland / Innovate UK	Naz Lone/Professor Matt Reed	Professor Matt Reed	Ongoing
Improving Care through Data Driven Innovation	Multimorbidity and Emergency Healthcare Provision: Improving Care through Data Driven Innovation	Wellcome Trust ISSF3	Naz Lone/Professor Matt Reed	Professor Matt Reed	Ongoing
EMERGE Biobank	A project to develop a prospective, consecutive, emergency, bio resource for emergency presentations	n/a	Professor Matt Reed	Professor Matt Reed	Ongoing

Current Research

Clinical Research

Innovation

Data projects